Achieving Tolerance with Perforin-Secreting Dendritic Cells
نویسندگان
چکیده
منابع مشابه
Dendritic Cells in Transplant Tolerance
Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient T cell responses following organ tr...
متن کاملdendritic cells in transplant tolerance
dendritic cells (dcs) are a heterogeneous family of professional apcs involved in priming adaptive immune responses. donor dcs (direct pathway of allorecognition) and recipient dcs presenting processed donor major histocompatibility complex (mhc) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient t cell responses following organ tr...
متن کاملDendritic cells in transplant tolerance.
Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient T cell responses following organ tr...
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Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is characterized by irregularly-shaped blood vessels with an inflammatory infiltrate. While absent from normal skin, plasmacytoid dendritic cells (pDCs) infiltrate the skin upon injury and during several infectious, inflammatory, and neoplastic entities. In addition to providing anti-viral resistance, pDCs link the innate and adapti...
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Oral tolerance prevents oral sensitization to dietary antigens (Ags), including proteins and haptens, and development of delayed-type hypersensitivity (DTH) responses. We showed here that plasmacytoid dendritic cells (pDCs) prevented oral T cell priming and were responsible for systemic tolerance to CD4(+) and CD8(+) T cell-mediated DTH responses induced by Ag feeding. Systemic depletion of pDC...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2016
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2015.11.008